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Abnormalities in the Brain 

Studies suggest that an imbalance of certain substances called neurotransmitters (chemical messengers ín the brain) may contribute to anxiety disorders. Advanced imaging techniques have revealed over-activity ín the locus ceruleus - the part of the brain important ín triggering a response to danger - ín people experiencing anxiety, indicating that some people’s brains may be more vulnerable to the disorder. Scientists are now beginning to identify the different areas of the brain associated with specific anxiety responses. 


Genetic Factors 

About 20-25% of close relatives of people with panic disorder or OCD experience these disorders. Researchers have identified a gene associated with people who have personality traits that include anxiety, anger, hostility, impulsiveness, pessimism & depression. The gene produces reduced amounts of a protein that transports serotonin, an important neurotransmitter for maintaining positive emotions. (This gene, however, would account for only a very small fraction of people with anxiety disorders.) Genetic mutations that affect other neurotransmitters have also been identified that contribute to OCD. 

 

 


Depression in Adolescence: Strong Predictor of GAD in Adulthood

Worry ís very common among children & ís often intense, but only about 5% have anxiety that can be classified as a disorder; moreover, depression ís a common companion ín such children. Studies have suggested that extremely shy children & those likely to be the target of bullies are at higher risk for developing anxiety disorders later ín life. One study suggests that such children could be identified as early as two years of age & possibly treated to avoid later anxiety disorders. 


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Prolonged television viewing also puts children at risk for anxiety, depression & behavioral problems. Panic disorders tend to begin ín late adolescence & peak at around 25 years of age. Signs of OCD can occur ín childhood, but usually develops fully ín adulthood. The risk for GAD spans a lifetime although ít appears to be the most common form of anxiety at older ages. 

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